The Marriage of Organocatalysis with Metal Catalysis: Access to Multisubstituted Chiral 2,5-Dihydropyrroles by Cascade Iminium/Enamine-Metal Cooperative Catalysis

被引：48

作者：

Sun, Wangsheng ^{[1
]}

Zhu, Gongming ^{[1
]}

Hong, Liang ^{[1
]}

Wang, Rui ^{[1
]}

机构：

[1] Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic Med Sci, Inst Biochem & Mol Biol,Sch Life Sci, Lanzhou 730000, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 50期

关键词：

aldehydes; cascade reaction; cooperative catalysis; organocatalysis; propargylamines; pyrrolines; FRIEDEL-CRAFTS ALKYLATION; ACTIVE THROMBIN INHIBITORS; TRANSITION-METAL; ALPHA; BETA-UNSATURATED ALDEHYDES; ENANTIOSELECTIVE SYNTHESIS; 3+2 CYCLOADDITION; GOLD CATALYSIS; MULTICOMPONENT REACTIONS; WATER; COMBINATION;

D O I：

10.1002/chem.201103083

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Organocatalyst and metal cooperate: The integration of iminium catalysis and enamine-metal cooperative catalysis into a single process facilitates the rapid and controlled production of valuable chiral pyrrolines in excellent diastereo- and enantioselectivities (see scheme). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：13958 / 13962

页数：5

共 90 条

[1]

[Anonymous], 2004, Angew. Chem, V116, P5248, DOI DOI 10.1002/ANGE.200400650

[2]

[Anonymous], 2011, ANGEW CHEM, DOI DOI 10.1021/JA8045519

[3]

Beller M., 2004, TRANSITION METALS OR

[4]

Berkessel A, 2005, ASYMMETRIC ORGANOCATALYSIS: FROM BIOMIMETIC CONCEPTS TO APPLICATIONS IN ASYMMETRIC SYNTHESIS, P1, DOI 10.1002/3527604677