A point mutation in CD45 may be associated with an increased risk of HIV-1 infection

被引：48

作者：

Tchilian, EZ ^{[1
]}

Wallace, DL

Dawes, R

Imami, N

Burton, C

Gotch, F

Beverley, PCL

机构：

[1] Edward Jenner Inst Vaccine Res, Compton, England

[2] Chelsea & Westminster Hosp, ICSM, Dept Immunol, London, England

来源：

AIDS | 2001年 / 15卷 / 14期

关键词：

D O I：

10.1097/00002030-200109280-00024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The CD45 antigen is essential for normal antigen receptor-mediated signalling in lymphocytes, and different patterns of splicing of CD45 are associated with distinct functions in lymphocytes. Here we show that abnormal CD45 splicing caused by a C77G transversion in exon A of the gene encoding CD45 (PTPRC) is associated with increased susceptibility to HIV-1 infection.

引用

收藏

页码：1892 / 1894

页数：3

相关论文

共 12 条

[1] ABNORMAL T-CELL PHENOTYPE IN FAMILIAL ERYTHROPHAGOCYTIC LYMPHOHISTIOCYTOSIS [J].

BUJAN, W ;

SCHANDENE, L ;

FERSTER, A ;

DEVALCK, C ;

GOLDMAN, M ;

SARIBAN, E .

LANCET, 1993, 342 (8882) :1296-1296

[2] CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4(+)CD8(+) thymocytes, and in B cell maturation [J].

Byth, KF ;

Conroy, LA ;

Howlett, S ;

Smith, AJH ;

May, J ;

Alexander, DR ;

Holmes, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1707-1718

[3] CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling [J].

Irie-Sasaki, J ;

Sasaki, T ;

Matsumoto, W ;

Opavsky, A ;

Cheng, M ;

Welstead, G ;

Griffiths, E ;

Krawczyk, C ;

Richardson, CD ;

Aitken, K ;

Iscove, N ;

Koretzky, G ;

Johnson, P ;

Liu, P ;

Rothstein, DM ;

Penninger, JM .

NATURE, 2001, 409 (6818) :349-354

[4] A point mutation in PTPRC is associated with the development of multiple sclerosis [J].

Jacobsen, M ;

Schweer, D ;

Ziegler, A ;

Gaber, R ;

Schock, S ;

Schwinzer, R ;

Wonigeit, K ;

Lindert, RB ;

Kantarci, O ;

Schaefer-Klein, J ;

Schipper, HI ;

Oertel, WH ;

Heidenreich, F ;

Weinshenker, BG ;

Sommer, N ;

Hemmer, B .

NATURE GENETICS, 2000, 26 (04) :495-499

[5] NORMAL B-LYMPHOCYTE DEVELOPMENT BUT IMPAIRED T-CELL MATURATION IN CD45-EXON6 PROTEIN-TYROSINE-PHOSPHATASE DEFICIENT MICE [J].

KISHIHARA, K ;

PENNINGER, J ;

WALLACE, VA ;

KUNDIG, TM ;

KAWAI, K ;

WAKEHAM, A ;

TIMMS, E ;

PFEFFER, K ;

OHASHI, PS ;

THOMAS, ML ;

FURLONGER, C ;

PAIGE, CJ ;

MAK, TW .

CELL, 1993, 74 (01) :143-156

[6]

Kozieradzki I, 1997, J IMMUNOL, V158, P3130

[7]

Kung C, 2000, NAT MED, V6, P343

[8] A deletion in the gene encoding the CD45 antigen in a patient with SCID [J].

Tchilian, EZ ;

Wallace, DL ;

Wells, RS ;

Flower, DR ;

Morgan, G ;

Beverley, PCL .

JOURNAL OF IMMUNOLOGY, 2001, 166 (02) :1308-1313

[9] A POINT MUTATION IN THE HUMAN CD45 GENE ASSOCIATED WITH DEFECTIVE SPLICING OF EXON-A [J].

THUDE, H ;

HUNDRIESER, J ;

WONIGEIT, K ;

SCHWINZER, R .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (07) :2101-2106

[10]

WAGNER R, 1995, CLIN EXP IMMUNOL, V99, P216