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Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling
被引:395
作者:

Yoo, Sang-Dong
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机构:
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

Cho, Young-Hee
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h-index: 0
机构:
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

Tena, Guillaume
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h-index: 0
机构:
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

Xiong, Yan
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h-index: 0
机构:
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

Sheen, Jen
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h-index: 0
机构:
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
机构:
[1] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA
来源:
关键词:
D O I:
10.1038/nature06543
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
A principal question in MAP kinase ( MAPK/ MPK) cascade signalling is how similar components dictate different specificity in the information- processing machineries from yeast to humans and plants. In Arabidopsis, how MPK3/ 6modulates distinct outputs in diverse signal transduction pathways remains elusive. By combining systematic cellular and genetic screens, here we uncover a previously unexpected MKK9 - MPK3/ MPK6 cascade promoting ethylene- insensitive 3 ( EIN3)- mediated transcription in ethylene signalling. The mkk9 mutant exhibits a broad spectrum of moderate ethylene- insensitive phenotypes, and translocated MKK9 governs nuclear signalling downstream of receptors. Breaking a linear model and conventional MAPK signalling, ethylene inactivates the negative regulator constitutive triple response 1 ( CTR1, a Raf- like MAPK kinase kinase ( MAPKKK)) to activate the positive MKK9 - MPK3/ 6 cascade. The bifurcate and antagonistic CTR1 and MKK9 pathways are both critical in determining ethylene- signalling specificity through two MAPK phosphorylation sites with opposite effects on EIN3 stability. The results suggest a new paradigm for linking intertwined MAPK cascades to control quantitative responses and specificity in signalling networks.
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页码:789 / U1
页数:8
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