Human chromosome 19 and related regions in mouse: Conservative and lineage-specific evolution

被引：173

作者：

Dehal, P

Predki, P

Olsen, AS

Kobayashi, A

Folta, P

Lucas, S

Land, M

Terry, A

Zhou, CLE

Rash, S

Zhang, Q

Gordon, L

Kim, J

Elkin, C

Pollard, MJ

Richardson, P

Rokhsar, D

Uberbacher, E

Hawkins, T

Branscomb, E

Stubbs, L ^{[1
]}

机构：

[1] DOE Joint, Genome Inst, Walnut Creek, CA 94598 USA

[2] Lawrence Livermore Natl Lab, Genome Div, Livermore, CA 94550 USA

[3] Lawrence Livermore Natl Lab, Div Engn, Livermore, CA 94550 USA

[4] Univ Calif Davis, Dept Genet, Davis, CA 95616 USA

[5] Univ Calif Berkeley, Lawrence Berkeley Lab, Genome Div, Berkeley, CA 94720 USA

[6] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Engn, Berkeley, CA 94720 USA

[7] Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA

[8] Oak Ridge Natl Lab, Div Life Sci, Oak Ridge, TN 37831 USA

来源：

SCIENCE | 2001年 / 293卷 / 5527期

关键词：

D O I：

10.1126/science.1060310

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To illuminate the function and evolutionary history of both genomes, we sequenced mouse DNA related to human chromosome 19. Comparative sequence alignments yielded confirmatory evidence for hypothetical genes and identified exons, regulatory elements, and candidate genes that were missed by other predictive methods. Chromosome-wide comparisons revealed a difference between single-copy HSA19 genes, which are overwhelmingly conserved in mouse, and genes residing in tandem familiar clusters, which differ extensively in number, coding capacity, and organization between the two species. Finally, we sequenced breakpoints of all 15 evolutionary rearrangements, providing a view of the forces that drive chromosome evolution in mammals.

引用

页码：104 / 111

页数：8

共 35 条

[1] Conserved interaction between distinct Kruppel-associated box domains and the transcriptional intermediary factor 1 β
Abrink, M
Ortiz, JA
Mark, C
Sanchez, C
Looman, C
Hellman, L
Chambon, P
Losson, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (04) : 1422 - 1426
[2] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, SF
Madden, TL
Schaffer, AA
Zhang, JH
Zhang, Z
Miller, W
Lipman, DJ
[J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (17) : 3389 - 3402
[3] An ordered comparative map of the cattle and human genomes
Band, MR
Larson, JH
Rebeiz, M
Green, CA
Heyen, DW
Donovan, J
Windish, R
Steining, C
Mahyuddin, P
Womack, JE
Lewin, HA
[J]. GENOME RESEARCH, 2000, 10 (09) : 1359 - 1368
[4] THE EVOLUTIONARILY CONSERVED KRUPPEL-ASSOCIATED BOX DOMAIN DEFINES A SUBFAMILY OF EUKARYOTIC MULTIFINGERED PROTEINS
BELLEFROID, EJ
PONCELET, DA
LECOCQ, PJ
REVELANT, O
MARTIAL, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) : 3608 - 3612
[5] Zooming in on the human-mouse comparative map: Genome conservation re-examined on a high-resolution scale
Carver, EA
Stubbs, L
[J]. GENOME RESEARCH, 1997, 7 (12) : 1123 - 1137
[6] A NOVEL FAMILY OF GENES ENCODING PUTATIVE PHEROMONE RECEPTORS IN MAMMALS
DULAC, C
AXEL, R
[J]. CELL, 1995, 83 (02) : 195 - 206
[7] Base-calling of automated sequencer traces using phred.: II.: Error probabilities
Ewing, B
Green, P
[J]. GENOME RESEARCH, 1998, 8 (03): : 186 - 194
[8] Felsenstein J, 1993, PHYLOGENY INFERENCE
[9] THE APOLIPOPROTEIN(A) GENE IS REGULATED BY SEX-HORMONES AND ACUTE-PHASE INDUCERS IN YAC TRANSGENIC MICE
FRAZER, KA
NARLA, G
ZHANG, JL
RUBIN, EM
[J]. NATURE GENETICS, 1995, 9 (04) : 424 - 431
[10] Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse
Gao, JL
Chen, H
Filie, JD
Kozak, CA
Murphy, PM
[J]. GENOMICS, 1998, 51 (02) : 270 - 276

← 1 2 3 4 →