The genetic factor in acute myocardial infarction with hypertension

被引：17

作者：

Aoki, S ^{[1
]}

Mukae, S ^{[1
]}

Itoh, S ^{[1
]}

Sato, R ^{[1
]}

Nishio, K ^{[1
]}

Iwata, T ^{[1
]}

Katagiri, T ^{[1
]}

机构：

[1] Showa Univ, Sch Med, Dept Internal Med 3, Shinagawa Ku, Tokyo 1428666, Japan

来源：

JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION | 2001年 / 65卷 / 07期

关键词：

acute myocardial infarction; angiotensin II receptor; bradykinin B2 receptor; essential hypertension; polymorphism;

D O I：

10.1253/jcj.65.621

中图分类号：

N09 [自然科学史]; B [哲学、宗教];

学科分类号：

01 ; 0101 ; 010108 ; 060207 ; 060305 ; 0712 ;

摘要：

This study assessed the contribution of polymorphisms of angiotensin II (AngII) receptors and bradykinin B2 (BK-B2) receptor to hypertension and acute myocardial infarction (AMI) in a Japanese population: 150 subjects with essential hypertension, 150 subjects with AMI with/without hypertension, and 150 healthy. age- and sex-matched controls. Polymorphisms of the AngII type 1 receptor (1166 A/C) and type 2 receptor (3123 C/A), and the BK-B2 receptor (-58T/C, exon 1) were analyzed and significant differences of genotypes and allelic frequencies in the AngII type 2 receptor C/A and BK-B2 receptor -58T/C were found between the essential hypertension and control subjects. Further, a significantly higher incidence of the C allele of the BK-B2 receptor was seen in AMI subjects with hypertension compared with those without hypertension. Genetic variations in the AngII and BK-B2 receptors could prove to be significant pathophysiological mechanisms affecting essential hypertension and AMI, and genetic differences appear to be a new risk factor for these conditions.

引用

页码：621 / 626

页数：6

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