Linezolid resistance in Staphylococcus aureus:: Gene dosage effect, stability, fitness costs, and cross-resistances

被引：114

作者：

Besier, Silke ^{[1
]}

Ludwig, Albrecht ^{[1
]}

Zander, Johannes ^{[1
]}

Brade, Volker ^{[1
]}

Wichelhaus, Thomas A. ^{[1
]}

机构：

[1] Klinikum JW Goethe Univ, Inst Med Mikrobiol & Krankenhaushyg, D-60596 Frankfurt, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 04期

关键词：

D O I：

10.1128/AAC.01098-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Linezolid resistance in Staphylococcus aureus is typically associated with mutations in the 23S rRNA gene. Here we show that the accumulation of a single point mutation, G2576T, in the different copies of this gene causes stepwise increases in resistance, impairment of the biological fitness, and cross-resistance to quinupristin-dalfopristin and chloramphenicol.

引用

页码：1570 / 1572

页数：3

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