Foxp3+CD4+ T cell-mediated immunosuppression involves extracellular nucleotide catabolism

被引：42

作者：

Bynoel, Margaret S. ^{[1
]}

Viret, Christophe ^{[2
,3
]}

机构：

[1] Cornell Univ, Coll Vet Med, Ithaca, NY 14853 USA

[2] Univ Toulouse 3, INSERM, U 563, F-31000 Toulouse, France

[3] CHU Purpan, F-31000 Toulouse, France

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 03期

关键词：

D O I：

10.1016/j.it.2007.12.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Foxp3(+)CD4(+) T cells represent a population of naturally arising suppressor T cells that are crucial for the control of autoimmune responses. The suppressive activity of this T cell subset relies on multiple mechanisms that include secretion of anti-inflammatory factors such as TGF-beta or IL-10. Novel studies now establish that, through the generation of the immunosuppressive factor adenosine, the ectoenzymes CD39 and CD73 are important contributors to the regulatory activity of Foxp3(+)CD4(+) T cells.

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页码：99 / 102

页数：4

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