A role for Numb in p53 stabilization

被引：39

作者：

Carter, Stephanie ^{[1
]}

Vousden, Karen H. ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

GENOME BIOLOGY | 2008年 / 9卷 / 05期

关键词：

D O I：

10.1186/gb-2008-9-5-221

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53.

引用

页数：3

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