Treatment of Helicobacter pylori and Chlamydia pneumoniae infections decreases fibrinogen plasma level in patients with ischemic heart disease

被引:77
作者
Torgano, G
Cosentini, R
Mandelli, C
Perondi, R
Blasi, F
Bertinieri, G
Van Tien, T
Ceriani, G
Tarsia, P
Arosio, C
Ranzi, ML
机构
[1] Osped Maggiore, IRCCS, Div Med Urgenza, Emergency Dept, I-20122 Milan, Italy
[2] Osped Maggiore, IRCCS, Inst Resp Dis, I-20122 Milan, Italy
[3] Osped Maggiore, IRCCS, Inst Hyg, I-20122 Milan, Italy
[4] Osped Maggiore, IRCCS, Hemodynam Unit, I-20122 Milan, Italy
关键词
ischemia; fibrinogen; H pylori; C pneumoniae;
D O I
10.1161/01.CIR.99.12.1555
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background-Chronic Chlamydia pneumoniae and Helicobacter pylori infections could be a risk factor for ischemic heart disease (IHD), possibly by increasing fibrinogen levels. The aim of our study was to evaluate changes in fibrinogen level in patients with IHD and H pylori and/or C pneumoniae positivity randomly assigned to antibiotic treatment. Methods and Results-Eighty-four patients with chronic IHD, H pylori and/or C pneumoniae antibodies, and normal acute-phase reactants were randomly assigned to treatment or no treatment. Treatment consisted of omeprazole, clarithromycin, and tinidazole in H pylori-positive patients and clarithromycin alone in C pneumoniae-positive patients. The effect of treatment and other baseline variables on fibrinogen levels, determined at 6 months, was evaluated by multivariate analysis. Treatment significantly reduced fibrinogen level at 6 months in the overall study population and in the groups of patients divided according to H pylori or C pneumoniae positivity. In the 43 treated patients, mean (+/- SD) basal fibrinogen was 3.65+/-0.58 g/L, and mean final Fibrinogen was 3.09+/-0.52 g/dL (P<0.001), whereas in the 41 untreated patients, mean basal and final fibrinogen levels were 3.45+/-0.70 and 3.61+/-0.71 g/L, respectively. The largest decrease was observed in patients with both infections. Fibrinogen changes were also significantly and negatively correlated with age. Conclusions-Our data suggest that a short, safe, and effective course of antibiotic therapy might be suggested as a means of interacting with an "emerging" risk factor.
引用
收藏
页码:1555 / 1559
页数:5
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