Four New Cytotoxic Tetrahydrofuranoid Lignans from Sinopodophyllum emodi

被引：35

作者：

Sun, Yan-Jun ^{[2
]}

Li, Zhan-Lin

Chen, Hong ^{[3
,4
]}

Liu, Xiao-Qiu

Zhou, Wei

Hua, Hui-Ming ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

[2] Henan Coll Tradit Chinese Med, Sch Pharm, Zhengzhou, Peoples R China

[3] Tianjin Key Lab Biomarkers Occupat & Environm Haz, Tianjin, Peoples R China

[4] Chinese Peoples Armed Police Force, Pharmacognosy Div, Coll Med, Tianjin, Peoples R China

来源：

PLANTA MEDICA | 2012年 / 78卷 / 05期

基金：

中国国家自然科学基金;

关键词：

tetrahydrofuranoid lignans; Sinopodophyllum emodi; Berberidaceae; cytotoxic activities; MAGNOLIA-FARGESII; FLOWER BUDS; GLYCOSIDES;

D O I：

10.1055/s-0031-1298201

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Four new tetrahydrofuranoid lignans, (-)-tanegool-7'-methyl ether (1), (+)-7'-methoxylariciresinol (2), sinolignan C (3), and epipinoresinol-4,4'-di-O-beta-D-glucopyranoside (4), were isolated from the roots and rhizomes of Sinopodophyllum emodi together with one known lignan (5). Their structures and stereochemistry were elucidated on the basis of spectroscopic and mass spectrometric evidence. The isolation of compounds 1-5 represents the first report of tetrahydrofuran lignans from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds were evaluated against HeLa and KB cell lines, and compound 1 showed the most potent cytotoxicity with IC50 values of 9.7 mu M and 4.7 mu M, respectively.

引用

页码：480 / 484

页数：5

共 22 条

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