Water-mediated catalyst preactivation: An efficient protocol for C-N cross-coupling reactions

被引：228

作者：

Fors, Brett P. ^{[1
]}

Krattiger, Philipp ^{[1
]}

Strieter, Eric ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 16期

关键词：

D O I：

10.1021/ol801285g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A protocol for forming a highly active Pd(0) catalyst from Pd(OAC)(2), water, and biaryldialkylphosphine ligands has been developed. This protocol generates a catalyst system, which exhibits excellent reactivity and efficiency in the coupling of a variety of amides and anilines with aryl chlorides.

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页码：3505 / 3508

页数：4

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