Behavioral and pathological outcomes in MOG 35-55 experimental autoimmune encephalomyelitis

被引：82

作者：

Jones, M. V. ^{[1
]}

Nguyen, T. T. ^{[1
]}

DeBoy, C. A. ^{[1
]}

Gniffin, J. W. ^{[1
]}

Whartenby, K. A. ^{[2
]}

Kerr, D. A. ^{[1
]}

Calabresi, P. A. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21287 USA

[2] Sidney Kimmel Comprehens Canc Ctr CRB I, Dept Oncol, Baltimore, MD 21231 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 199卷 / 1-2期

关键词：

EAE; multiple sclerosis; T cells; microglia; axons;

D O I：

10.1016/j.jneuroim.2008.05.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

We measured inflammatory and neural markers of disease from 7 days to one year after induction of experimental autoimmune encephalomyelitis (EAE) by immunization with myelin oligodendrocyte glycoprotein (MOG) peptide. Axon loss began before behavioral signs when T cell infiltration and microglial activation were very subtle. Remyelination was only detectable ultrastructurally. Axon numbers in the dorsal column plateau around day 30 p.i. while behavioral measures (EAE scores, rotarod, grip strength) partially recover. These results provide a starting point for testing potential neuroprotective treatments I or multiple sclerosis (MS). (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：83 / 93

页数：11

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