Declining HCV seroprevalence in pregnant women with HIV

被引:6
作者
Floridia, M. [1 ]
Tamburrini, E. [2 ]
Anzidei, G. [3 ]
Tibaldi, C. [4 ,5 ]
Muggiasca, M. L. [6 ,7 ]
Guaraldi, G. [8 ]
Fiscon, M. [9 ]
Vimercati, A. [10 ,11 ]
Martinelli, P. [12 ]
Donisi, A. [13 ]
Dalzero, S. [14 ]
Ravizza, M. [14 ]
机构
[1] Ist Super Sanita, Dept Therapeut Res & Med Evaluat, I-00161 Rome, Italy
[2] Catholic Univ, Dept Infect Dis, Rome, Italy
[3] INMI Lazzaro Spallanzani, Rome, Italy
[4] Univ Turin, Dept Obstet & Gynecol, Turin, Italy
[5] AO OIRM S Anna, Turin, Italy
[6] Univ Milan, Dept Obstet & Gynecol, Milan, Italy
[7] L Sacco Hosp Vialba, Milan, Italy
[8] Univ Modena & Reggio Emilia, Dept Med Special, Infect Dis Clin, Modena, Italy
[9] Univ Padua, Dept Pediat, Padua, Italy
[10] Univ Bari, Dept Obstet & Gynecol, Bari, Italy
[11] Policlin Hosp, Bari, Italy
[12] Univ Naples Federico 2, Dept Obstet & Gynaecol, Naples, Italy
[13] Azienda Osped Piacenza, Infect Dis Unit, Piacenza, Italy
[14] S Paolo Hosp, Dept Obstet & Gynecol, Milan, Italy
关键词
Africa; HIV; HCV; pregnancy; women; HEPATITIS-C VIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; VERTICAL TRANSMISSION; INFECTED PATIENTS; NATURAL-HISTORY; COINFECTION; PREVALENCE; EUROPE; METAANALYSIS; COHORT;
D O I
10.1017/S0950268810000129
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
We assessed recent trends in hepatitis C virus (HCV) prevalence in pregnant women with HIV using data from a large national study. Based on 1240 pregnancies, we observed a 3.4-fold decline in HCV seroprevalence in pregnant women with HIV between 2001 (29.3%) and 2008(8.6%). This decline was the net result of two components: a progressively declining HCV seroprevalence in non-African women (from 35.7% in 2001 to 16.7% in 2008), sustained by a parallel reduction in history of injecting drug use (IDU) in this population, and a significantly growing presence (from 21.2% in 2001 to 48.6% in 2008) of women of African origin, at very low risk of being HCV-infected [average HCV prevalence 1%, adjusted odds ratio (aOR) for HCV 0.09, 95% CI 0.03-0.29]. Previous IDU was the stronger determinant of HCV co-infection in pregnant women with HIV (aOR 30.9, 95% CI 18.8-51.1). The observed trend is expected to translate into a reduced number of cases of vertical HCV transmission.
引用
收藏
页码:1317 / 1321
页数:5
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