Prognostic Significance of Anti-Aminoacyl-tRNA Synthetase Antibodies in Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease: A Retrospective Case Control Study

被引：77

作者：

Hozumi, Hironao ^{[1
]}

Enomoto, Noriyuki ^{[1
]}

Kono, Masato ^{[1
]}

Fujisawa, Tomoyuki ^{[1
]}

Inui, Naoki ^{[2
]}

Nakamura, Yutaro ^{[1
]}

Sumikawa, Hiromitsu ^{[3
]}

Johkoh, Takeshi ^{[4
]}

Nakashima, Ran ^{[5
]}

Imura, Yoshitaka ^{[5
]}

Mimori, Tsuneyo ^{[5
]}

Suda, Takafumi ^{[1
]}

机构：

[1] Hamamatsu Univ, Sch Med, Dept Internal Med, Div 2, Hamamatsu, Shizuoka 4312102, Japan

[2] Hamamatsu Univ, Sch Med, Dept Clin Pharmacol & Therapeut, Hamamatsu, Shizuoka 4312102, Japan

[3] Osaka Univ, Grad Sch Med, Diagnost & Intervent Radiol, Suita, Osaka, Japan

[4] Kinki Cent Hosp, Mutual Aid Assoc, Publ Sch Teachers, Dept Radiol, Itami, Hyogo, Japan

[5] Kyoto Univ, Grad Sch Med, Dept Rheumatol & Clin Immunol, Kyoto, Japan

来源：

PLOS ONE | 2015年 / 10卷 / 03期

关键词：

MYOSITIS-SPECIFIC AUTOANTIBODIES; AMYOPATHIC DERMATOMYOSITIS; CLINICAL-FEATURES; GENE; 5; POLYMYOSITIS; MANIFESTATIONS; CLASSIFICATION; AUTOANTIGEN; SOCIETY; HRCT;

D O I：

10.1371/journal.pone.0120313

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Background In polymyositis/dermatomyositis (PM/DM), anti-aminoacyl-tRNA synthetase (ARS) antibodies are closely associated with interstitial lung disease (ILD), a frequent pulmonary complication. However, the clinical significance of anti-ARS antibodies is not well established. Objective We aimed to evaluate the clinical significance of anti-ARS antibodies in PM/DM-ILD patients. Methods Forty-eight consecutive PM/DM-ILD patients were studied retrospectively. Anti-ARS antibodies were screened by ELISA and confirmed by RNA immunoprecipitation test. Medical records, high-resolution computed tomography images, and surgical lung biopsy specimens were compared between ARS-positive (ARS group) and ARS-negative patients (non-ARS group). Results Anti-ARS antibodies were detected in 23 of 48 patients (48%). Radiologically, nonspecific interstitial pneumonia (NSIP) pattern was observed more frequently in the ARS group than in the non-ARS group (73.9% vs. 40%, P = 0.02). Pathologically, NSIP was the most frequent in both groups. Ten-year survival rate was also significantly higher in the ARS group than in the non-ARS group (91.6% vs. 58.7%, P = 0.02). Univariate Cox hazards analysis revealed that the presence of anti-ARS antibodies was associated with better prognosis (HR = 0.34, 95% CI 0.08-0.80; P = 0.01). Conclusions The presence of anti-ARS antibodies is a possible prognostic marker in patients with PM/DM-ILD.

引用

页数：14

共 39 条

[1]

Patients with non-Jo-1 anti-tRNA-synthetase autoantibodies have worse survival than Jo-1 positive patients [J].