Synthesis of amphiphilic polyhydroxylated pyrrolidines as potential glycosidase inhibitors

被引：16

作者：

Esposito, A ^{[1
]}

Falorni, M ^{[1
]}

Taddei, M ^{[1
]}

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 36期

关键词：

pyrrolidines; antivirals; enzyme inhibitors; cyclisation;

D O I：

10.1016/S0040-4039(98)01361-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several polyhydroxylated pyrrolidines with an aliphatic long chain on the ring nitrogen were prepared starting from D-mannitol. An amphiphilic bis-azasugar scaffold has been also prepared. These products behave as cationic surfactants and show a promising anti HIV-I activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6543 / 6546

页数：4

共 9 条

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