Acetylsalicylic acid reduces ischemia-induced proliferation of dentate cells in gerbils

被引:36
作者
Kumihashi, K
Uchida, K
Miyazaki, H
Kobayashi, U
Tsushima, T
Machida, T
机构
[1] Saitama Univ, Grad Sch Sci & Engn, Dept Regulat Biol, Urawa, Saitama 3388570, Japan
[2] Tokyo Med & Dent Univ, Fac Dent, Dept Oral & Maxillofacial Surg 1, Bunkyo Ku, Tokyo 1138549, Japan
关键词
acetylsalicylic acid; cell proliferation; cyclooxygenase; dentate gyrus; ischemia;
D O I
10.1097/00001756-200104170-00010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Transient global ischemia causes neurogenesis in the dentate gyrus of adult rodents. Ischemic insults to rodents also induce cyclooxygenase-2 (COX-2), an isoform of cyclooxygenases (COXs) and a rate-limiting enzyme for prostanoid synthesis. In the present experiments, adult Mongolian gerbils were chronically treated with acetylsalicylic acid (ASA), a non-selective COX inhibitor, and the proliferation of cells in the dentate gyrus was examined under ischemia. It was proved that BrdU-labeled cells in the dentate gyrus were significantly reduced in number following ASA treatment after 10 min global ischemia. The result strongly suggests that COX, probably COX-2, and prostanoids play an important role in the proliferation of neural cells after ischemia in gerbils. NeuroReport 12:915-917 (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码:915 / 917
页数:3
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