p27 destruction: Cks1 pulls the trigger

被引：28

作者：

Bartek, J ^{[1
]}

Lukas, J ^{[1
]}

机构：

[1] Danish Canc Soc, Inst Canc Biol, Dept Cell Cycle & Canc, DK-2100 Copenhagen, Denmark

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 04期

关键词：

D O I：

10.1038/35070160

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent work has discovered the role of the cyclin-dependent kinase (CDK)-binding protein Cks1 in degrading the CDK inhibitor p27(Kip1). This process is essential for DNA replication and is aberrantly enhanced in cancer. Surprisingly, new work indicates that this function of Cks1 is independent of CDKs and links Cks1 with the Skp2 subunit of the SCF ubiquitin ligase.

引用

页码：E95 / E98

页数：4

共 16 条

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