Reversible diabetes mellitus during growth hormone therapy in chronic renal failure

被引：10

作者：

Filler, G ^{[1
]}

Franke, D ^{[1
]}

Amendt, P ^{[1
]}

Ehrich, JHH ^{[1
]}

机构：

[1] Humboldt Univ, Charite Childrens Hosp, Dept Pediat Nephrol, D-10117 Berlin, Germany

来源：

PEDIATRIC NEPHROLOGY | 1998年 / 12卷 / 05期

关键词：

recombinant human growth hormone; chronic renal failure; diabetes; intravenous glucose tolerance test; idiopathic Fanconi syndrome;

D O I：

10.1007/s004670050475

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A 12-year-old girl with short stature due to idiopathic Fanconi syndrome and chronic renal failure was treated with recombinant human growth hormone (rhGH). Then was no family history of diabetes mellitus and the glucose tolerance before treatment was normal. Intravenous glucose tolerance tests were performed before, during and after treatment. Two months after starting rhGH the early phase of insulin secretion (1-+3-min values) was diminished, and the patient developed manifest diabetes mellitus with hyperglycemia and an elevated hemoglobin Ale. Following discontinuation of rhGH, glucose tolerance slowly returned to normal.

引用

页码：405 / 407

页数：3

共 15 条

[1] GLUCOSE-INDUCED INSULIN-SECRETION IN UREMIA - RELATION WITH ACID-BASE-BALANCE AND EFFECTS OF BICARBONATE ADMINISTRATION [J].

ALLEGRA, V ;

MENGOZZI, G ;

MARTIMBIANCO, L ;

VASILE, A .

NEPHRON, 1993, 63 (01) :43-48

[2] INSULIN RESISTANCE IN UREMIA [J].

DEFRONZO, RA ;

ALVESTRAND, A ;

SMITH, D ;

HENDLER, R ;

HENDLER, E ;

WAHREN, J .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (02) :563-568

[3]

EHRICH JHH, 1992, NEPHROL DIAL TRANSPL, V7, P36

[4] RECOMBINANT HUMAN GROWTH-HORMONE TREATMENT OF CHILDREN WITH CHRONIC-RENAL-FAILURE - LONG-TERM (1-YEAR TO 3-YEAR) OUTCOME [J].

FINE, RN ;

PYKEGRIMM, K ;

NELSON, PA ;

BOECHAT, MI ;

LIPPE, BM ;

YADIN, O ;

KAMIL, E .

PEDIATRIC NEPHROLOGY, 1991, 5 (04) :477-481

[5]

HENQUIN JC, 1994, JOSLINS DIABETES MEL, P57

[6] EFFECT OF GROWTH-HORMONE TREATMENT ON GLUCOSE-TOLERANCE IN A PATIENT WITH CYSTINOSIS AFTER KIDNEY-TRANSPLANTATION [J].

KOHLHAUSER, C ;

BALZAR, E ;

SCHOBER, E ;

FRISCH, H .

KLINISCHE PADIATRIE, 1995, 207 (03) :106-108

[7] Growth hormone as a new treatment modality for short children with chronic renal failure [J].

Mehls, O ;

Haffner, D ;

Wuhl, E ;

Tonshoff, B ;

Schaefer, F ;

Heinrich, U ;

Bittner, K ;

Ehrich, JHH ;

Filler, G ;

Gellermann, J ;

Hampel, H ;

Bachmann, H ;

Ruder, H ;

Bonzel, KE ;

Scheller, B ;

Dippell, J ;

Zimmerhackl, LB ;

Kreuder, J ;

Rascher, W ;

MullerWiefel, DE ;

Misselwitz, J ;

Ronnefarth, B ;

Querfeld, U ;

Eichstadt, H ;

Greiner, C ;

Keller, E ;

Weber, HP ;

Heise, HR ;

Wiemann, D ;

Beetz, R ;

Sasse, D ;

Soergel, M ;

Pistor, K ;

Zlotkowski, A ;

Klare, B ;

Eife, R ;

KuwertzBroking, E ;

Wigger, M ;

Mix, M ;

Eicher, O .

HORMONE RESEARCH, 1996, 46 (4-5) :230-235

[8] GROWTH-RESPONSE TO RECOMBINANT HUMAN GROWTH-HORMONE IN SHORT PREPUBERTAL CHILDREN WITH CHRONIC-RENAL-FAILURE WITH OR WITHOUT DIALYSIS [J].

MEHLS, O ;

BROYER, M ;

ALBERTSSONWIKLAND, K ;

ALLEN, B ;

BAUR, L ;

BEETZ, R ;

BERG, U ;

BONZEL, K ;

CARRASCOSA, A ;

COWELL, C ;

CRAWFORD, B ;

DAVIN, JC ;

DELVALLE, CJ ;

DIPPELL, J ;

GARCIA, L ;

GASKIN, K ;

HAFFNER, D ;

HODSON, EM ;

JANSSEN, F ;

JODAL, U ;

JUREIDINI, K ;

KLARE, B ;

KNIGHT, F ;

KUWERTZBROCKING, E ;

LORIS, C ;

MAES, M ;

MUELLERWIEFEL, DE ;

NAVARRO, M ;

PENFOLD, J ;

PISTOR, K ;

PREECE, M ;

RAPPAPORT, R ;

RASHER, W ;

REES, L ;

RIGDEN, SPA ;

RIVASCRESPO, M ;

ROY, LP ;

RUDER, H ;

SASSE, D ;

SILINK, M ;

SIPILA, I ;

STREHLAN, J ;

STUBBE, P ;

TONSHOFF, B ;

VANDERSCHUERENLODEWEYCKX, M ;

WEBER, HP ;

WUHL, E ;

ZIMMERHACKL, L .

ACTA PAEDIATRICA, 1994, 83 :81-87

[9]

SCHMITZ O, 1993, J PEDIATR ENDOCRINOL, V6, P53

[10]

SCHMITZ O, 1991, DAN MED BULL, V38, P36

← 1 2 →