Head-to-tail peptide cyclodimerization by copper-catalyzed azide-alkyne cycloaddition

被引：187

作者：

Punna, S ^{[1
]}

Kuzelka, J ^{[1
]}

Wang, Q ^{[1
]}

Finn, MG ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 15期

关键词：

alkynes; azides; cycloaddition; dimerization; peptides;

D O I：

10.1002/anie.200461656

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Rings forged with copper: Oligopeptide cyclodimerization occurs selectively when precursors containing azide and alkyne groups are exposed to copper(I) ions on polystyrene supports (see picture; Prot = protecting group). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：2215 / 2220

页数：6

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