Protein kinase C inhibitors attenuate protective effect of high glucose against hypoxic injury in H9c2 cardiac cells

被引：15

作者：

Moon, CH ^{[1
]}

Jung, YS ^{[1
]}

Kim, MH ^{[1
]}

Park, RM ^{[1
]}

Lee, SH ^{[1
]}

Baik, EJ ^{[1
]}

机构：

[1] Ajou Univ, Dept Physiol, Sch Med, Paldal Gu, Suwon 442749, South Korea

来源：

JAPANESE JOURNAL OF PHYSIOLOGY | 2000年 / 50卷 / 06期

关键词：

high glucose; cardioprotection; PKC;

D O I：

10.2170/jjphysiol.50.645

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

In this study, we demonstrated that PKC inhibitors significantly attenuated the cardioprotective effect produced by high-glucose (22 mM) treatment for 48 h against hypoxic injury in H9c2 cardiac cells. PKC activators mimicked the cardioprotective effect of high glucose. These results suggest a possible role of PKC activation in high-glucose-induced protection.

引用

页码：645 / 649

页数：5

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