Emulsification of liposomes with incomplete Freund's adjuvant: Stability of the liposomes and the emulsion

被引：5

作者：

Muderhwa, JM ^{[1
]}

Rothwell, SW

Alving, CR

机构：

[1] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Membrane Biochem, Washington, DC 20307 USA

[2] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Hematol & Vasc Biol, Washington, DC 20307 USA

[3] Jenner Biotherapies Inc, San Ramon, CA 94583 USA

来源：

JOURNAL OF LIPOSOME RESEARCH | 1998年 / 8卷 / 02期

关键词：

D O I：

10.3109/08982109809035525

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Emulsification of liposomes with incomplete Freund's adjuvant, a water-in-oil emulsion, resulted in the formation of stable emulsions containing a large fraction of intact liposomes. Although some loss of liposome integrity and loss of emulsion stability did occur at certain concentrations of liposomes, based on the release of trapped glucose, it was determined that formulations of Freund's adjuvant containing liposomes could be produced that still retained a considerable liposomal permeability barrier for at least 7 days.

引用

页码：183 / 194

页数：12

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