Analysis of diltiazem and its related substances by HPLC and HPLC/MS

被引：13

作者：

Quaglia, MG

Donati, E

Fanali, S

Bossù, E

Montinaro, A

Buiarelli, F

机构：

[1] Univ Roma La Sapienza, Dipartimento Farmaceut, I-00185 Rome, Italy

[2] CNR, Ist Metodol Chim, I-00016 Monterotondo, Italy

[3] Ist Super Sanita, I-00161 Rome, Italy

[4] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2005年 / 37卷 / 04期

关键词：

diltiazem; impurities; classical reversed stationary phases; monolithic support; HPLC; HPLC/MS;

D O I：

10.1016/j.jpba.2004.11.050

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Diltiazem (DTZ) is an optically active calcium channel blocker having a benzodiazepine structure. The drug used in therapy is (+)-cis-diltiazem with configuration (2S, 3S). To describe the analytical profile of DTZ different stationary phases (RP-18, RP-8, monolithic support) were tested. The best separation of DTZ from A, 13, E and F was obtained using as stationary phase a RP-8 or a monolithic RP-18. The characterization of impurities was carried out using two analytical systems, HPLC and HPLC/MS. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：695 / 701

页数：7

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