Steroid metabolism in breast cancer: Where are we and what are we missing?

被引：27

作者：

Africander, Donita ^{[1
]}

Storbeck, Karl-Heinz ^{[1
]}

机构：

[1] Stellenbosch Univ, Dept Biochem, ZA-7600 Stellenbosch, South Africa

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2018年 / 466卷

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

Breast cancer; Intracrinology; Estrogens; Androgens; Progestogens; Glucocorticoids; GLUCOCORTICOID-RECEPTOR EXPRESSION; MESSENGER-RNA EXPRESSION; DEHYDROGENASE TYPE-II; ESTROGEN-RECEPTOR; ANDROGEN RECEPTOR; PROGESTERONE METABOLITES; ADRENAL ANDROGENS; IN-SITU; 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-1; 5-ALPHA-DIHYDROPROGESTERONE; 5-ALPHA-P;

D O I：

10.1016/j.mce.2017.05.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

It is well-known that breast cancer is hormone-dependent and that steroid hormones exert their mitogenic effects by binding to estrogen, progesterone and androgen receptors. Vital to our understanding and treatment of this malignancy, is the local metabolism of steroid hormones in breast cancer tissue. This review summarises our current knowledge on steroid producing pathways in the adrenal, ovary and breast, while focussing on the availability of specific circulating hormone precursors and steroidogenic enzymes involved in the local synthesis and metabolism of steroid hormones in the breast. Consequently, we highlight alternate pathways that may be instrumental in the etiology of breast cancer. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：86 / 97

页数：12

共 171 条

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