A functional genetic variation of the 5-HT2a receptor affects human memory

被引：115

作者：

de Quervain, DJF ^{[1
]}

Henke, K ^{[1
]}

Aerni, A ^{[1
]}

Coluccia, D ^{[1
]}

Wollmer, MA ^{[1
]}

Hock, C ^{[1
]}

Nitsch, RM ^{[1
]}

Papassotiropoulos, A ^{[1
]}

机构：

[1] Univ Zurich, Div Psychiat Res, CH-8029 Zurich, Switzerland

来源：

NATURE NEUROSCIENCE | 2003年 / 6卷 / 11期

关键词：

D O I：

10.1038/nn1146

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Human memory capacity is highly variable across individuals and is influenced by both genetic and environmental factors. A roughly 50% heritability estimate(1) indicates that naturally occurring genetic variations have an important impact on this cognitive ability. Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant.

引用

页码：1141 / 1142

页数：2

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