Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma

被引：17

作者：

Sükösd, F

Digon, B

Fischer, J

Pietsch, T

Kovacs, G

机构：

[1] Univ Heidelberg, Dept Urol, Mol Oncol Lab, Heidelberg, Germany

[2] Univ Bonn, Dept Neuropathol, D-5300 Bonn, Germany

来源：

CANCER GENETICS AND CYTOGENETICS | 2001年 / 128卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(01)00413-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromophobe renal cell carcinoma (RCC) is characterized by loss of multiple chromosomes including chromosome 10. This study was undertaken to determine the LOH at the PTEN/MMAC1 locus (chromosome band 10q23.3) and to search for gene mutations in 15 chromophobe, 50 conventional, and 10 papillary RCCs as well as in 10 renal oncocytomas. Loss of heterozygosity (LOH) wa seen at all informative loci in all chromophobe RCCs and in two conventional RCCs. We did not find mutations by analyzing exon 1 to 9 of the PTEN/MMAC1 gene using the PCR-SSCP technique in tumors with LOFT at 10q23.3. (C) 2001 Elsevier Science inc. All rights reserved.

引用

页码：161 / 163

页数：3

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