Interleukin-6 in the aging brain

被引：129

作者：

Godbout, JP ^{[1
]}

Johnson, RW ^{[1
]}

机构：

[1] Univ Illinois, Dept Anim Sci, Lab Integrat Biol, Urbana, IL 61801 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 147卷 / 1-2期

关键词：

aging; brain; cytokines; interleukin-6; mice; microglia;

D O I：

10.1016/j.jneuroim.2003.10.031

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Astrocytes, microglia, and neurons express the cytokine interleukin-6 (IL-6), which in the brain has been suggested to reduce food intake, inhibit memory and learning, cause neurodegeneration, and exacerbate sickness behavior induced by other cytokines. Recent evidence indicates IL-6 levels are increased in brain of healthy aged animals, thus it may play a role in the neurophysiological manifestations of old age. The purpose of this brief report is to discuss the new evidence that suggests an age-related increase in brain IL-6 and the impact this inflammatory cytokine may have on "successful" aging. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：141 / 144

页数：4

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