The ErbB receptor tyrosine family as signal integrators

被引：117

作者：

Hynes, NE ^{[1
]}

Horsch, K ^{[1
]}

Olayioye, MA ^{[1
]}

Badache, A ^{[1
]}

机构：

[1] Friedrich Miescher Inst, CH-4002 Basel, Switzerland

来源：

关键词：

D O I：

10.1677/erc.0.0080151

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ErbB receptor tyrosine kinases (RTKs) and their ligands have important roles in normal development and in human cancer. Among the ErbB receptors only ErbB2 has no direct ligand; however, ErbB2 acts as a co-receptor for the other family members, promoting high affinity ligand binding and enhancement of ligand-induced biological responses. These characteristics demonstrate the central role of ErbB2 in the receptor family, which likely explains why it is involved in the development of many human malignancies, including breast cancer. ErbB RTKs also function as signal integrators, cross-regulating different classes of membrane receptors including receptors of the cytokine family. Cross-regulation of ErbB RTKs and cytokines receptors represents another mechanism for controlling and enhancing tumor cell proliferation.

引用

页码：151 / 159

页数：9

共 51 条

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