Synthesis of 3-(1, 3-Diphenyl-1H-pyrazol-4-yl) Propanoic Acids Using Diimide Reduction

被引：4

作者：

Deepa, M. ^{[1
]}

Babu, V. Harinadha ^{[1
]}

Parameshwar, R. ^{[1
]}

Reddy, B. Madhava ^{[1
]}

机构：

[1] G Pulla Reddy Coll Pharm, Dept Pharmaceut Chem, Hyderabad 500028, Andhra Pradesh, India

来源：

E-JOURNAL OF CHEMISTRY | 2012年 / 9卷 / 01期

关键词：

Pyrazole acrylic acids; Pyrazole propanoic acids; Diimide method; PYRAZOLE DERIVATIVES;

D O I：

10.1155/2012/481682

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Pyrazole-1H-4-yl-acrylic acids (3a-j) were prepared from pyrazole-1H-4-carbaldehydes which in turn were prepared by the Vilsmeier-Haack reaction of phenyl hydrazone derivatives (1a-j). The reaction of pyrazole-1H-4-yl-acrylic acids to 3-(1, 3-diphenyl-1H-pyrazol-4-yl) propanoic acids (4a-j) was carried out using Pd-charcoal and diimide methods and % yields were compared. Though the yields may be slightly less in diimide method, the method was found to be economical, highly effective with simple operating procedure.

引用

页码：420 / 424

页数：5

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