Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

被引：459

作者：

Graham, Robert R. ^{[2
]}

Cotsapas, Chris ^{[2
,3
,4
]}

Davies, Leela ^{[2
]}

Hackett, Rachel ^{[2
]}

Lessard, Christopher J. ^{[1
,5
]}

Leon, Joanlise M. ^{[6
]}

Burtt, Noel P. ^{[2
]}

Guiducci, Candace ^{[2
]}

Parkin, Melissa ^{[2
]}

Gates, Casey ^{[2
]}

Plenge, Robert M. ^{[2
]}

Behrens, Timothy W. ^{[7
]}

Wither, Joan E. ^{[8
,9
,10
,11
]}

Rioux, John D. ^{[12
,13
]}

Fortin, Paul R. ^{[10
,14
]}

Graham, Deborah Cunninghame ^{[15
]}

Wong, Andrew K. ^{[15
]}

Vyse, Timothy J. ^{[15
]}

Daly, Mark J. ^{[2
,3
,4
]}

Altshuler, David ^{[2
]}

Moser, Kathy L. ^{[1
]}

Gaffney, Patrick M. ^{[1
]}

机构：

[1] Oklahoma Med Res Fdn, Arthritis & Immunol Res Program, Oklahoma City, OK 73104 USA

[2] Harvard & MIT, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA

[3] Harvard Univ, Sch Med, Mass Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Dept Med, Boston, MA 02114 USA

[5] Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK 73104 USA

[6] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN 55455 USA

[7] Genentech Inc, San Francisco, CA 94080 USA

[8] Arthritis Ctr Excellence, Toronto, ON, Canada

[9] Univ Hlth Network, Toronto Western Hosp, Res Inst, Div Genet & Dev, Toronto, ON, Canada

[10] Univ Toronto, Dept Med, Toronto, ON, Canada

[11] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[12] Univ Montreal, Montreal, PQ H3C 3J7, Canada

[13] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada

[14] Univ Hlth Network, Univ Toronto Lupus Clin, Ctr Prognosis Studies Rheumat Dis, Toronto Western Hosp, Toronto, ON, Canada

[15] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Mol Genet & Rheumatol Sect, London, England

来源：

NATURE GENETICS | 2008年 / 40卷 / 09期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

D O I：

10.1038/ng.200

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10-(12), OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis ( RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.

引用

页码：1059 / 1061

页数：3

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