A graphene/zinc oxide nanocomposite film protects dental implant surfaces against cariogenic Streptococcus mutans

被引：116

作者：

Kulshrestha, Shatavari ^{[1
]}

Khan, Shakir ^{[1
]}

Meena, Ramovatar ^{[3
]}

Singh, Braj R. ^{[2
]}

Khan, Asad U. ^{[1
]}

机构：

[1] Aligarh Muslim Univ, Interdisciplinary Biotechnol Unit, Aligarh, Uttar Pradesh, India

[2] Aligarh Muslim Univ, Ctr Excellence Mat Sci Nanomat, Aligarh, Uttar Pradesh, India

[3] Jawaharlal Nehru Univ, Sch Environm Sci, New Delhi 110067, India

来源：

BIOFOULING | 2014年 / 30卷 / 10期

关键词：

graphene/zinc oxide nanocomposite; dental caries; acrylic teeth; dental implants; cytotoxicity; anti-biofilm; BIOFILM FORMATION; ANTIBACTERIAL ACTIVITY; SILVER NANOPARTICLES; ZINC-OXIDE; PHOTOCATALYTIC ACTIVITY; ZNO NANOPARTICLES; INHIBITION; ADHERENCE; AGENT; CYTOTOXICITY;

D O I：

10.1080/08927014.2014.983093

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Oral biofilms play a crucial role in the development of dental caries and other periodontal diseases. Streptococcus mutans is one of the primary etiological agents in dental caries. Implant systems are regularly employed to replace missing teeth. Oral biofilms accumulate on these implants and are the chief cause of dental implant failure. In the present study, the potential of graphene/zinc oxide nanocomposite (GZNC) against the cariogenic properties of Streptococcus mutans was explored and the anti-biofilm behaviour of artificial acrylic teeth surfaces coated with GZNC was examined. Acrylic teeth are a good choice for implants as they are low cost, have low density and can resist fracture. Microscopic studies and anti-biofilm assays showed a significant reduction in biofilm in the presence GZNC. GZNC was also found to be nontoxic against HEK-293 (human embryonic kidney cell line). The results indicate the potential of GZNC as an effective coating agent for dental implants by efficiently inhibiting S. mutans biofilms.

引用

页码：1281 / 1294

页数：14

共 58 条

[1]

The Collagen-Binding Protein Cnm Is Required for Streptococcus mutans Adherence to and Intracellular Invasion of Human Coronary Artery Endothelial Cells [J].