共 44 条
Helicobacter pylori tissue tropism:: mouse-colonizing strains can target different gastric niches
被引:52
作者:

Akada, JK
论文数: 0 引用数: 0
h-index: 0
机构: Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

Ogura, K
论文数: 0 引用数: 0
h-index: 0
机构: Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

Dailidiene, D
论文数: 0 引用数: 0
h-index: 0
机构: Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

Dailide, G
论文数: 0 引用数: 0
h-index: 0
机构: Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

Cheverud, JM
论文数: 0 引用数: 0
h-index: 0
机构: Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

Berg, DE
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
机构:
[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA
来源:
MICROBIOLOGY-SGM
|
2003年
/
149卷
关键词:
D O I:
10.1099/mic.0.26129-0
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Studies with the mouse-adapted Helicobacter pylori strain SS 1 had supported an idea that infections by this pathogen start in the gastric antrum and spread to the corpus after extensive mucosal damage. This paper shows that the unrelated strain X47 colonizes the corpus preferentially. Differences between strains in preferred gastric region were detected by co-inoculating mice with a mixture of SS1 and X47, and genotyping H. pylori recovered after 2-8 weeks of infection by vacA s allele PCR and RAPID fingerprinting. Mixed infections were found in each of 59 co-inoculated young C57BL/6J mice. On average, however, SS1 was fourfold more abundant than X47 in the antrum and X47 was threefold more abundant than SS1 in the corpus. Similar results were obtained in mice inoculated first with one strain and then the other strain 2 weeks later. SS1 was even more abundant in the antrum of elderly (> 1 year old) mice (97% of isolates). Qualitatively similar SS1 and X47 tissue distributions were seen using unrelated mouse lines (AKR/J, A/J, DBA/2J, BALB/cJ, LG/J, SM/J), but with significantly different SS1 : X47 ratios in some cases. These results suggest the existence of at least two distinct gastric niches whose characteristics may be affected by host genotype and age (physiology), and indicate that strains differ in how effectively they colonize each niche. Differences among gastric regions and the mixed infections that these allow may contribute to H. pylori diversity and genome evolution.
引用
收藏
页码:1901 / 1909
页数:9
相关论文
共 44 条
[1]
Recombination and clonal groupings within Helicobacter pylori from different geographical regions
[J].
Achtman, M
;
Azuma, T
;
Berg, DE
;
Ito, Y
;
Morelli, G
;
Pan, ZJ
;
Suerbaum, S
;
Thompson, SA
;
van der Ende, A
;
van Doorn, LJ
.
MOLECULAR MICROBIOLOGY,
1999, 32 (03)
:459-470

Achtman, M
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Mol Genet, D-14195 Berlin, Germany

Azuma, T
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Mol Genet, D-14195 Berlin, Germany

Berg, DE
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Mol Genet, D-14195 Berlin, Germany

Ito, Y
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Mol Genet, D-14195 Berlin, Germany

Morelli, G
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Mol Genet, D-14195 Berlin, Germany

Pan, ZJ
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Mol Genet, D-14195 Berlin, Germany

Suerbaum, S
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Mol Genet, D-14195 Berlin, Germany

Thompson, SA
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Mol Genet, D-14195 Berlin, Germany

论文数: 引用数:
h-index:
机构:

van Doorn, LJ
论文数: 0 引用数: 0
h-index: 0
机构: Max Planck Inst Mol Genet, D-14195 Berlin, Germany
[2]
DNA DIVERSITY AMONG CLINICAL ISOLATES OF HELICOBACTER-PYLORI DETECTED BY PCR-BASED RAPD FINGERPRINTING
[J].
AKOPYANZ, N
;
BUKANOV, NO
;
WESTBLOM, TU
;
KRESOVICH, S
;
BERG, DE
.
NUCLEIC ACIDS RESEARCH,
1992, 20 (19)
:5137-5142

AKOPYANZ, N
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,CAMPUS BOX 8230,ST LOUIS,MO 63110

BUKANOV, NO
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,CAMPUS BOX 8230,ST LOUIS,MO 63110

WESTBLOM, TU
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,CAMPUS BOX 8230,ST LOUIS,MO 63110

KRESOVICH, S
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,CAMPUS BOX 8230,ST LOUIS,MO 63110

BERG, DE
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,CAMPUS BOX 8230,ST LOUIS,MO 63110
[3]
Modulating phagocyte activation:: The pros and cons of Helicobacter pylori virulence factors
[J].
Allen, LAH
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2000, 191 (09)
:1451-1454

Allen, LAH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Iowa, Dept Med, Iowa City, IA 52242 USA
[4]
Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
[J].
Alm, RA
;
Ling, LSL
;
Moir, DT
;
King, BL
;
Brown, ED
;
Doig, PC
;
Smith, DR
;
Noonan, B
;
Guild, BC
;
deJonge, BL
;
Carmel, G
;
Tummino, PJ
;
Caruso, A
;
Uria-Nickelsen, M
;
Mills, DM
;
Ives, C
;
Gibson, R
;
Merberg, D
;
Mills, SD
;
Jiang, Q
;
Taylor, DE
;
Vovis, GF
;
Trost, TJ
.
NATURE,
1999, 397 (6715)
:176-180

Alm, RA
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Ling, LSL
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Moir, DT
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

King, BL
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Brown, ED
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Doig, PC
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Smith, DR
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Noonan, B
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Guild, BC
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

deJonge, BL
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Carmel, G
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Tummino, PJ
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Caruso, A
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Uria-Nickelsen, M
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Mills, DM
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Ives, C
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Gibson, R
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Merberg, D
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Mills, SD
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Jiang, Q
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Taylor, DE
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Vovis, GF
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA

Trost, TJ
论文数: 0 引用数: 0
h-index: 0
机构: Astra Res Ctr Boston, Cambridge, MA 02139 USA
[5]
Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells
[J].
Amieva, MR
;
Salama, NR
;
Tompkins, LS
;
Falkow, S
.
CELLULAR MICROBIOLOGY,
2002, 4 (10)
:677-690

Amieva, MR
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

Salama, NR
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

Tompkins, LS
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

Falkow, S
论文数: 0 引用数: 0
h-index: 0
机构: Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA
[6]
MOSAICISM IN VACUOLATING CYTOTOXIN ALLELES OF HELICOBACTER-PYLORI - ASSOCIATION OF SPECIFIC VACA TYPES WITH CYTOTOXIN PRODUCTION AND PEPTIC-ULCERATION
[J].
ATHERTON, JC
;
CAO, P
;
PEEK, RM
;
TUMMURU, MKR
;
BLASER, MJ
;
COVER, TL
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1995, 270 (30)
:17771-17777

ATHERTON, JC
论文数: 0 引用数: 0
h-index: 0
机构: VANDERBILT UNIV,SCH MED,DEPT MED,DIV INFECT DIS,NASHVILLE,TN 37232

CAO, P
论文数: 0 引用数: 0
h-index: 0
机构: VANDERBILT UNIV,SCH MED,DEPT MED,DIV INFECT DIS,NASHVILLE,TN 37232

PEEK, RM
论文数: 0 引用数: 0
h-index: 0
机构: VANDERBILT UNIV,SCH MED,DEPT MED,DIV INFECT DIS,NASHVILLE,TN 37232

TUMMURU, MKR
论文数: 0 引用数: 0
h-index: 0
机构: VANDERBILT UNIV,SCH MED,DEPT MED,DIV INFECT DIS,NASHVILLE,TN 37232

BLASER, MJ
论文数: 0 引用数: 0
h-index: 0
机构: VANDERBILT UNIV,SCH MED,DEPT MED,DIV INFECT DIS,NASHVILLE,TN 37232

COVER, TL
论文数: 0 引用数: 0
h-index: 0
机构: VANDERBILT UNIV,SCH MED,DEPT MED,DIV INFECT DIS,NASHVILLE,TN 37232
[7]
TOPOGRAPHIC ASSOCIATION BETWEEN ACTIVE GASTRITIS AND CAMPLYLOBACTER-PYLORI COLONIZATION
[J].
BAYERDORFFER, E
;
OERTEL, H
;
LEHN, N
;
KASPER, G
;
MANNES, GA
;
SAUERBRUCH, T
;
STOLTE, M
.
JOURNAL OF CLINICAL PATHOLOGY,
1989, 42 (08)
:834-839

BAYERDORFFER, E
论文数: 0 引用数: 0
h-index: 0
机构: MUNICIPAL HOSP BOGENHAUSEN,INST MICROBIOL,MUNICH,FED REP GER

OERTEL, H
论文数: 0 引用数: 0
h-index: 0
机构: MUNICIPAL HOSP BOGENHAUSEN,INST MICROBIOL,MUNICH,FED REP GER

LEHN, N
论文数: 0 引用数: 0
h-index: 0
机构: MUNICIPAL HOSP BOGENHAUSEN,INST MICROBIOL,MUNICH,FED REP GER

KASPER, G
论文数: 0 引用数: 0
h-index: 0
机构: MUNICIPAL HOSP BOGENHAUSEN,INST MICROBIOL,MUNICH,FED REP GER

MANNES, GA
论文数: 0 引用数: 0
h-index: 0
机构: MUNICIPAL HOSP BOGENHAUSEN,INST MICROBIOL,MUNICH,FED REP GER

SAUERBRUCH, T
论文数: 0 引用数: 0
h-index: 0
机构: MUNICIPAL HOSP BOGENHAUSEN,INST MICROBIOL,MUNICH,FED REP GER

STOLTE, M
论文数: 0 引用数: 0
h-index: 0
机构: MUNICIPAL HOSP BOGENHAUSEN,INST MICROBIOL,MUNICH,FED REP GER
[8]
Helicobacter pylori populations in Peruvian patients
[J].
Berg, DE
;
Gilman, RH
;
LelwalaGuruge, J
;
Srivastava, K
;
Valdez, Y
;
Watanabe, J
;
Miyagi, J
;
Akopyants, NS
;
RamirezRamos, A
;
Yoshiwara, TH
;
Recavarren, S
;
LeonBarua, R
.
CLINICAL INFECTIOUS DISEASES,
1997, 25 (05)
:996-1002

Berg, DE
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

Gilman, RH
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

LelwalaGuruge, J
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

Srivastava, K
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

Valdez, Y
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

Watanabe, J
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

Miyagi, J
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

Akopyants, NS
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

RamirezRamos, A
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

Yoshiwara, TH
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

Recavarren, S
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

LeonBarua, R
论文数: 0 引用数: 0
h-index: 0
机构: WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA
[9]
Identification of loci essential for the growth of Helicobacter pylori under acidic conditions
[J].
Bijlsma, JJE
;
Lie-A-Ling, M
;
Nootenboom, IC
;
Vandenbroucke-Grauls, CMJE
;
Kusters, JG
.
JOURNAL OF INFECTIOUS DISEASES,
2000, 182 (05)
:1566-1569

Bijlsma, JJE
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam, Fac Med, Dept Med Microbiol, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam, Fac Med, Dept Med Microbiol, NL-1081 BT Amsterdam, Netherlands

Lie-A-Ling, M
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam, Fac Med, Dept Med Microbiol, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam, Fac Med, Dept Med Microbiol, NL-1081 BT Amsterdam, Netherlands

Nootenboom, IC
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam, Fac Med, Dept Med Microbiol, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam, Fac Med, Dept Med Microbiol, NL-1081 BT Amsterdam, Netherlands

Vandenbroucke-Grauls, CMJE
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam, Fac Med, Dept Med Microbiol, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam, Fac Med, Dept Med Microbiol, NL-1081 BT Amsterdam, Netherlands

Kusters, JG
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam, Fac Med, Dept Med Microbiol, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam, Fac Med, Dept Med Microbiol, NL-1081 BT Amsterdam, Netherlands
[10]
Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori
[J].
Björkholm, B
;
Sjölund, M
;
Falk, PG
;
Berg, OG
;
Engstrand, L
;
Andersson, DI
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2001, 98 (25)
:14607-14612

Björkholm, B
论文数: 0 引用数: 0
h-index: 0
机构: Swedish Inst Infect Dis Control, S-17182 Solna, Sweden

Sjölund, M
论文数: 0 引用数: 0
h-index: 0
机构: Swedish Inst Infect Dis Control, S-17182 Solna, Sweden

Falk, PG
论文数: 0 引用数: 0
h-index: 0
机构: Swedish Inst Infect Dis Control, S-17182 Solna, Sweden

Berg, OG
论文数: 0 引用数: 0
h-index: 0
机构: Swedish Inst Infect Dis Control, S-17182 Solna, Sweden

Engstrand, L
论文数: 0 引用数: 0
h-index: 0
机构: Swedish Inst Infect Dis Control, S-17182 Solna, Sweden

Andersson, DI
论文数: 0 引用数: 0
h-index: 0
机构:
Swedish Inst Infect Dis Control, S-17182 Solna, Sweden Swedish Inst Infect Dis Control, S-17182 Solna, Sweden