Fas-ligand mediated apoptosis in severe sepsis and shock

被引：21

作者：

Ayala, A

Lomas, JL

Grutkoski, PS

Chung, CS

机构：

[1] Rhode Isl Hosp, Div Surg Res, Providence, RI 02903 USA

[2] Brown Univ, Sch Med, Div Surg Res, Providence, RI 02903 USA

[3] Brown Univ, Sch Med, Dept Surg, Providence, RI 02903 USA

来源：

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2003年 / 35卷 / 09期

关键词：

D O I：

10.1080/00365540310015656

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Alterations in the apoptotic process in lymphoid tissues is a common condition which is encountered in the severely septic animal and critically ill patient. Here we attempt to delineate the pathological significance of these apoptotic changes and the role of Fas-FasL mediated contribution to this process.

引用

收藏

页码：593 / 600

页数：8

相关论文

共 84 条

[1] Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care [J].

Angus, DC ;

Linde-Zwirble, WT ;

Lidicker, J ;

Clermont, G ;

Carcillo, J ;

Pinsky, MR .

CRITICAL CARE MEDICINE, 2001, 29 (07) :1303-1310

[2] Does FAS ligand or endotoxin contribute to thymic apoptosis during polymicrobial sepsis? [J].

Ayala, A ;

Xu, YX ;

Chung, CS ;

Chaudry, IH .

SHOCK, 1999, 11 (03) :211-217

[3] Differential induction of apoptosis in lymphoid tissues during sepsis: Variation in onset, frequency, and the nature of the mediators [J].

Ayala, A ;

Herdon, CD ;

Lehman, DL ;

Ayala, CA ;

Chaudry, IH .

BLOOD, 1996, 87 (10) :4261-4275

[4] Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin-mediated process [J].

Ayala, A ;

Xu, YX ;

Ayala, CA ;

Sonefeld, DE ;

Karr, SM ;

Evans, TA ;

Chaudry, IH .

BLOOD, 1998, 91 (04) :1362-1372

[5] THE INDUCTION OF ACCELERATED THYMIC PROGRAMMED CELL-DEATH DURING POLYMICROBIAL SEPSIS - CONTROL BY CORTICOSTEROIDS BUT NOT TUMOR-NECROSIS-FACTOR [J].

AYALA, A ;

HERDON, CD ;

LEHMAN, DL ;

DEMASO, CM ;

AYALA, CA ;

CHAUDRY, IH .

SHOCK, 1995, 3 (04) :259-267

[6] IL-10 mediation of activation-induced Th1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis [J].

Ayala, A ;

Chung, CS ;

Song, GY ;

Chaudry, IH .

CYTOKINE, 2001, 14 (01) :37-48

[7]

AYALA A, 2002, IN PRESS AM J PATHOL, V161

[8]

BARKE RA, 1994, ARCH SURG-CHICAGO, V129, P1256

[9] Neutrophils are primed for cytotoxicity and resist apoptosis in injured patients at risk for multiple organ failure [J].

Biffl, WL ;

Moore, EE ;

Zallen, G ;

Johnson, JL ;

Gabriel, J ;

Offner, PJ ;

Silliman, CC .

SURGERY, 1999, 126 (02) :198-202

[10]

Castro A, 1998, EUR J IMMUNOL, V28, P488, DOI 10.1002/(SICI)1521-4141(199802)28:02<488::AID-IMMU488>3.0.CO

← 1 2 3 4 5 6 7 8 9 →