A B cell-based sensor for rapid identification of pathogens

被引：183

作者：

Rider, TH ^{[1
]}

Petrovick, MS

Nargi, FE

Harper, JD

Schwoebel, ED

Mathews, RH

Blanchard, DJ

Bortolin, LT

Young, AM

Chen, JZ

Hollis, MA

机构：

[1] MIT, Lincoln Lab, Lexington, MA 02420 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

[3] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

来源：

SCIENCE | 2003年 / 301卷 / 5630期

关键词：

D O I：

10.1126/science.1084920

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report the use of genetically engineered cells in a pathogen identification sensor. This sensor uses B lymphocytes that have been engineered to emit light within seconds of exposure to specific bacteria and viruses. We demonstrated rapid screening of relevant samples and identification of a variety of pathogens at very low levels. Because of its speed, sensitivity, and specificity, this pathogen identification technology could prove useful for medical diagnostics, biowarfare defense, food- and water-quality monitoring, and other applications.

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页码：213 / 215

页数：3

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