Synthesis of 3,4,3 LI 1,2 HOPO labelled with 14C.

被引：11

作者：

Burgada, R

Bailly, T

Noël, JP

Gomis, JM

Valleix, A

Ansoborlo, E

Hengé-Napoli, MH

Paquet, F

Gourmelon, P

机构：

[1] CEA Saclay, Serv Mol Marquees, F-91191 Gif Sur Yvette, France

[2] Univ Paris 13, Lab Chim Struct Biomol, F-93017 Bobigny, France

[3] Inst Protect & Surete Nucl, Dept Protect Sante Homme & Dosimetrie, Serv Dosimetrie, Pierrelatte, France

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2001年 / 44卷 / 01期

关键词：

carbon; 14; LIHOPO; decorporation; actinide;

D O I：

10.1002/jlcr.427

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

3,4,3 LI 1,2 HOPO 1 or LIHOPO (1,5,10,14-tetra (1-hydroxy-2-pyridone-6-oyl)-1,5,10,14-tetraazatetradecane.) is a decorporation agent used against actinides. It was synthesised labelled with carbon 14 with a view to metabolism studies. [6,9-C-14]-LIHOPO 2 was obtained in two radioactive steps through a very convenient synthesis in 50% radioactive yield from commercially available [1,4-C-14]-spermine, hydrochloride and 1-benzyloxy-6-oxo-1,6-dihydropyridine-2-carbonyl chloride 7. The synthesis of 7 is also described.

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页码：13 / 19

页数：7

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