Folk medicine Terminalia catappa and its major tannin component, punicalagin, are effective against bleomycin-induced genotoxicity in Chinese hamster ovary cells

被引：86

作者：

Chen, PS

Li, JH

Liu, TY

Lin, TC

机构：

[1] Natl Bur Controlled Drugs, Dept Hlth, Execut Yuan, Taipei, Taiwan

[2] Natl Yang Ming Univ, Inst Genet, Taipei 112, Taiwan

[3] Vet Gen Hosp, Dept Med Res, Taipei, Taiwan

[4] Ta Jen Pharmaceut Coll, Dept Pharm, Pingtung, Taiwan

来源：

CANCER LETTERS | 2000年 / 152卷 / 02期

关键词：

bleomycin; Terminalia catappa; punicalagin; reactive oxygen species; anti-genotoxic effect;

D O I：

10.1016/S0304-3835(99)00395-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Terminalia catappa L. is a popular folk medicine for preventing hepatoma and treating hepatitis in Taiwan. In this paper, we examined the protective effects of T. catappa leaf water extract (TCE) and its major tannin component, punicalagin, on bleomycin-induced genotoxicity in cultured Chinese hamster ovary cells. Pre-treatment with TCE or punicalagin prevented bleomycin-induced hgprt gene mutations and DNA strand breaks. TCE and punicalagin suppressed the generation of bleomycin-induced intracellular free radicals, identified as superoxides and hydrogen peroxides. The effectiveness of TCE and punicalagin against bleomycin-induced genotoxicity could be, at least in part, due to their antioxidative potentials. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：115 / 122

页数：8

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