Localization of brain-type fatty acid-binding protein in Kupffer cells of mice and its transient decrease in response to lipopolysaccharide

被引：29

作者：

Abdelwahab, SA ^{[1
]}

Owada, Y ^{[1
]}

Kitanaka, N ^{[1
]}

Iwasa, H ^{[1
]}

Sakagami, H ^{[1
]}

Kondo, H ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med Sci, Div Histol, Dept Cell Biol, Sendai, Miyagi 9808575, Japan

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 2003年 / 119卷 / 06期

关键词：

brain; liver; Kupffer cell; fatty acid binding protein; lipopolysaccharide;

D O I：

10.1007/s00418-003-0538-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Brain-type fatty acid-binding protein (BFABP) was localized in Kupffer cells of liver of postnatal day 10 (P10) and older mice in immunolight and electron microscopy as well as by in situ hybridization histochemistry. The immunoreaction products were localized in the cytoplasmic matrix but not within the nucleus. After peritoneal injection of lipopolysaccharide (LPS), the immunoreaction for B-FABP decreased markedly in Kupffer cells at 1 h postinjection and thereafter gradually recovered to the preinjection level by 24 h postinjection, although no decrease in the mRNA expression was detected in Northern blotting throughout the course after the injection. The specific localization of B-FABP, but not the other FABPs, in Kupffer cells, and its rapid decrease after LPS injection suggest the intimate involvement of B-FABP in Kupffer cells in the inflammatory reaction, probably through mediation of n-3 polyunsaturated fatty acids, which are strong binders of B-FABP.

引用

页码：469 / 475

页数：7

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