Polyamine-dependent gene expression

被引:320
作者
Childs, AC
Mehta, DJ
Gerner, EW
机构
[1] Univ Arizona, Arizona Canc Ctr, Dept Biochem & Biophys, Tucson, AZ 85724 USA
[2] Univ Arizona, Arizona Canc Ctr, Dept Cellular & Mol Biol, Tucson, AZ 85724 USA
[3] Univ Arizona, Arizona Canc Ctr, Dept Radiat Oncol, Tucson, AZ 85724 USA
关键词
polyamines; RNA; gene expression; casein kinase 2; aggregation;
D O I
10.1007/s00018-003-2332-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The polyamines spermidine and spermine along with the diamine putrescine are involved in many cellular processes, including chromatin condensation, maintenance of DNA structure, RNA processing, translation and protein activation. The polyamines influence the formation of compacted chromatin and have a well-established role in DNA aggregation. Polyamines are used in the posttranslational modification of eukaryotic initiation factor 5A, which regulates the transport and processing of specific RNA. The polyamines also participate in a novel RNA-decoding mechanism, a translational frame-shift, of at least two known genes, the TY1 transposon and mammalian antizyme. Polyamines are crucial for their own regulation and are involved in feedback mechanisms affecting both polyamine synthesis and catabolism. Recently, it has become apparent that the polyamines are able to influence the action of the protein kinase casein kinase 2. Here we address several roles of polyamines in gene expression.
引用
收藏
页码:1394 / 1406
页数:13
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