Molecular biology - A big development for a small RNA

被引:20
作者
Clayton, DA [1 ]
机构
[1] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA
关键词
D O I
10.1038/35065191
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The RNA-processing enzyme MRP contains an RNA component that is essential for its activity. Unexpectedly, it seems that mutations in the gene encoding this RNA cause a multifaceted human disease.
引用
收藏
页码:29 / 31
页数:2
相关论文
共 11 条
[1]  
Cai T, 1999, MOL CELL BIOL, V19, P7857
[2]   A MAMMALIAN MITOCHONDRIAL RNA PROCESSING ACTIVITY CONTAINS NUCLEUS-ENCODED RNA [J].
CHANG, DD ;
CLAYTON, DA .
SCIENCE, 1987, 235 (4793) :1178-1184
[4]   A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice [J].
Johnson, KR ;
Zheng, QY ;
Bykhovskaya, Y ;
Spirina, O ;
Fischel-Ghodsian, N .
NATURE GENETICS, 2001, 27 (02) :191-194
[5]  
MCKUSICK VA, 1965, B J HOPKINS HOSP, V116, P231
[6]   A functional dominant mutation in Schizosaccharomyces pombe RNase MRP RNA affects nuclear RNA processing and requires the mitochondrial-associated nuclear mutation ptp1-1 for viability [J].
Paluh, JL ;
Clayton, DA .
EMBO JOURNAL, 1996, 15 (17) :4723-4733
[7]   Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia [J].
Ridanpää, M ;
van Eenennaam, H ;
Pelin, K ;
Chadwick, R ;
Johnson, C ;
Yuan, B ;
vanVenrooij, W ;
Pruijn, G ;
Salmela, R ;
Rockas, S ;
Mäkitie, O ;
Kaitila, I ;
de la Chapelle, A .
CELL, 2001, 104 (02) :195-203
[8]   YEAST SITE-SPECIFIC RIBONUCLEOPROTEIN ENDORIBONUCLEASE MRP CONTAINS AN RNA COMPONENT HOMOLOGOUS TO MAMMALIAN RNASE MRP RNA AND ESSENTIAL FOR CELL VIABILITY [J].
SCHMITT, ME ;
CLAYTON, DA .
GENES & DEVELOPMENT, 1992, 6 (10) :1975-1985
[9]   Mutational analysis of the RNA component of Saccharomyces cerevisiae RNase MRP reveals distinct nuclear phenotypes [J].
Shadel, GS ;
Buckenmeyer, GA ;
Clayton, DA ;
Schmitt, ME .
GENE, 2000, 245 (01) :175-184
[10]   CARTILAGE-HAIR HYPOPLASIA GENE ASSIGNED TO CHROMOSOME-9 BY LINKAGE ANALYSIS [J].
SULISALO, T ;
SISTONEN, P ;
HASTBACKA, J ;
WADELIUS, C ;
MAKITIE, O ;
DELACHAPELLE, A ;
KAITILA, I .
NATURE GENETICS, 1993, 3 (04) :338-341