Mitochondrial complex III: An essential component of universal oxygen sensing machinery?

被引：49

作者：

Chandel, Navdeep S. ^{[1
,2
]}

机构：

[1] Div Pulm & Crit Care Med, Dept Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA

来源：

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2010年 / 174卷 / 03期

关键词：

Erythropoiesis; Pulmonary vasoconstriction; Hypoxia; Carotid Body; ROS; ACTIVATED PROTEIN-KINASE; HYPOXIC PULMONARY VASOCONSTRICTION; INDUCIBLE FACTOR-I; CAROTID-BODY EXCITATION; DNA-BINDING ACTIVITY; GP91 PHOX SUBUNIT; NADPH OXIDASE; HIF-ALPHA; UPSTREAM KINASE; NAD(P)H OXIDASE;

D O I：

10.1016/j.resp.2010.08.004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Oxygen is necessary for the survival of mammalian cells. In order to maintain adequate cellular oxygenation, mammals have evolved multiple acute and long-term adaptive responses to hypoxia. These include hypoxic increases in erythropoiesis, pulmonary vasoconstriction and carotid body neurosecretion. Collectively, these responses help maintain oxygen homeostasis as oxygen levels remain scarce. There are multiple effectors proposed to underlie these diverse responses to hypoxia including PHD2, AMPK, NADPH oxidases, and mitochondria! complex III. Here I propose a model wherein complex III is integral to oxygen sensing in regulating diverse response to hypoxia. (C) 2010 Elsevier B.V. All rights reserved.

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页码：175 / 181

页数：7

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