Coupling cell growth, proliferation, and death: Hippo weighs in

被引：37

作者：

Hay, BA

Guo, M

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

[2] Univ Calif Los Angeles, Sch Med, Brain Res Inst, Dept Neurol, Los Angeles, CA 90095 USA

来源：

DEVELOPMENTAL CELL | 2003年 / 5卷 / 03期

关键词：

D O I：

10.1016/S1534-5807(03)00270-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Four recent papers describe the characterization in Drosophila of Hippo, a serine/threonine kinase of the Sterile 20 (STE20) group, resembling Mst1 and Mst2. Hippo restricts cell growth and cell proliferation, promotes cell death, and interacts with the tumor suppressors Salvador and Warts. This, together with the ability of Mst2 to rescue hippo mutant phenotypes, argues that Mst/Hippo proteins are tumor suppressors.

引用

页码：361 / 363

页数：3

共 10 条

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