Granulysin

被引：89

作者：

Clayberger, C ^{[1
]}

Krensky, AM ^{[1
]}

机构：

[1] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(03)00097-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Granulysin, a molecule expressed by human natural killer cells and activated T lymphocytes, exhibits cytolytic activity against a variety of microbes and tumors. Progress in understanding the structure, function and clinical relevance of granulysin over the past year encompasses three main areas: first, the solution of its crystal structure, providing new insights into its potential mechanism of target cell damage; second, inhibition of its function with small interfering RNA, indicating its relevance in microbial immunity; and third, association of granulysin expression in natural killer cells with good outcomes in cancer, indicating its potential utility as a diagnostic and suggesting its relevance to human disease.

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页码：560 / 565

页数：6

相关论文

共 37 条

[1] Granulysin crystal structure and a structure-derived lytic mechanism [J].

Anderson, DH ;

Sawaya, MR ;

Cascio, D ;

Ernst, W ;

Modlin, R ;

Krensky, A ;

Eisenberg, D .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 325 (02) :355-365

[2] Identification of an anti-mycobacterial domain in NK-lysin and granulysin [J].

Andreu, D ;

Carreño, C ;

Linde, C ;

Boman, HG ;

Andersson, M .

BIOCHEMICAL JOURNAL, 1999, 344 :845-849

[3] CD4+ and CD8+ T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism [J].

Canaday, DH ;

Wilkinson, RJ ;

Li, Q ;

Harding, CV ;

Silver, RF ;

Boom, WH .

JOURNAL OF IMMUNOLOGY, 2001, 167 (05) :2734-2742

[4] Selective depression of interferon-γ and granulysin production with increase of proliferative response by Vγ9/Vδ T cells in children with tuberculosis [J].

Dieli, F ;

Sireci, G ;

Caccamo, N ;

Di Sano, C ;

Titone, L ;

Romano, A ;

Di Carlo, P ;

Barera, A ;

Accardo-Palumbo, A ;

Krensky, AM ;

Salerno, A .

JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (12) :1835-1839

[5] Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vγ9/Vδ2 T lymphocytes [J].

Dieli, F ;

Troye-Blomberg, M ;

Ivanyi, J ;

Fournié, JJ ;

Krensky, AM ;

Bonneville, M ;

Peyrat, MA ;

Caccamo, N ;

Sireci, G ;

Salerno, A .

JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (08) :1082-1085

[6] Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis [J].

Ericson, KG ;

Fadeel, B ;

Andersson, M ;

Gudmundsson, GH ;

Gürgey, A ;

Yalman, N ;

Janka, G ;

Nordenskjöld, M ;

Henter, JI .

HUMAN GENETICS, 2003, 112 (01) :98-99

[7] Granulysin, a T cell product, kills bacteria by altering membrane permeability [J].

Ernst, WA ;

Thoma-Uszynski, S ;

Teitelbaum, P ;

Ko, C ;

Hanson, DA ;

Clayberger, C ;

Krensky, AM ;

Leippe, M ;

Bloom, BR ;

Ganz, T ;

Modlin, RL .

JOURNAL OF IMMUNOLOGY, 2000, 165 (12) :7102-7108

[8]

Gamen S, 1998, J IMMUNOL, V161, P1758

[9] Antimicrobial activity and stability to proteolysis of small linear cationic peptides with D-amino acid substitutions [J].

Hamamoto, K ;

Kida, Y ;

Zhang, Y ;

Shimizu, T ;

Kuwano, K .

MICROBIOLOGY AND IMMUNOLOGY, 2002, 46 (11) :741-749

[10] Biosynthesis of granulysin, a novel cytolytic molecule [J].

Hanson, DA ;

Kaspar, AA ;

Poulain, FR ;

Krensky, AM .

MOLECULAR IMMUNOLOGY, 1999, 36 (07) :413-422

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