Links between the immune and coagulation systems: How do "Antiphospholipid antibodies" cause thrombosis?

被引：12

作者：

Hoffman, M ^{[1
]}

Monroe, DM

Roubey, RAS

机构：

[1] Vet Adm Med Ctr, Durham, NC 27705 USA

[2] Duke Univ, Durham, NC USA

来源：

IMMUNOLOGIC RESEARCH | 2000年 / 22卷 / 2-3期

关键词：

lupus anticoagulant; antiphospholipid syndrome; autoimmunity; thrombosis; tissue factor; blood monocyte;

D O I：

10.1385/IR:22:2-3:191

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammation and immune activation have been associated with thrombosis in a number of settings. We have been interested in the question of how the presence of a type of autoantibody, so-called "antiphospholipid" antibody, leads to thrombosis. Several mechanisms have been proposed including modulation of tissue factor expression, enhancement of procoagulant binding to platelets, and interference with antithrombotic mechanisms. We developed a cell-based model of coagulation that, unlike current coagulation assays, reflects some of the in vivo activities of "antiphospholipid" antibodies. "Antiphospholipid" antibodies against the phospholipid-binding protein beta-2-glycoprotein-1 enhance thrombin generation in this model system, primarily by enhancing procoagulant reactions on tissue factor-bearing cells.

引用

页码：191 / 197

页数：7

共 16 条

[1] Thrombosis in primary antiphospholipid syndrome - A pivotal role for monocyte tissue factor expression [J].