Biodegradable pH-sensing dendritic nanoprobes for near-infrared fluorescence lifetime and intensity imaging

被引：106

作者：

Almutairi, Adah ^{[1
]}

Guillaudeu, Steven J. ^{[1
]}

Berezin, Mikhail Y. ^{[2
]}

Achilefu, Samuel ^{[2
]}

Frechet, Jean M. J. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Coll Chem, Berkeley, CA 94720 USA

[2] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 02期

关键词：

D O I：

10.1021/ja078147e

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

The overproduction of acidic by products is implicated in the development of numerous diseases, and there is currently great interest in developing contrast agents that can image acidic tissue in vivo. Here we report a biodegradable pH-sensing near-infrared (NIB) nanoprobe capable of providing both fluorescence intensity amplification and lifetime information. The pH-sensing NIR nanoprobe is synthesized, in six high yielding and scalable steps, and functions within the tissue transparency window. Both fluorescence intensity and lifetime provided complementary physiological (low pH) and molecular (released fluorophore binding to albumin) information, respectively.

引用

页码：444 / +

页数：3

共 24 条

[1]

Ratiometric analysis of fluorescence lifetime for probing binding sites in albumin with near-infrared fluorescent molecular probes [J].

Berezin, Mikhail Y. ;

Lee, Hyeran ;

Akers, Walter ;

Nikiforovich, Gregory ;

Achilefu, Samuel .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2007, 83 (06) :1371-1378

[2]

Whole-body fluorescence lifetime imaging of a tumor-targeted near-infrared molecular probe in mice [J].

Bloch, S ;

Lesage, F ;

McIntosh, L ;

Gandjbakhche, A ;

Liang, KX ;

Achilefu, S .

JOURNAL OF BIOMEDICAL OPTICS, 2005, 10 (05)

[3]

Stark spectroscopy of size-selected helical H-aggregates of a cyanine dye templated by duplex DNA. Effect of exciton coupling on electronic polarizabilities [J].

Chowdhury, A ;

Yu, LP ;

Raheem, I ;

Peteanu, L ;

Liu, LA ;

Yaron, DJ .

JOURNAL OF PHYSICAL CHEMISTRY A, 2003, 107 (18) :3351-3362

[4]

Polyester dendritic systems for drug delivery applications:: In vitro and in vivo evaluation [J].

De Jesús, OLP ;

Ihre, HR ;

Gagne, L ;

Fréchet, JMJ ;

Szoka, FC .

BIOCONJUGATE CHEMISTRY, 2002, 13 (03) :453-461

[5]

Porphyrin and tetrabenzoporphyrin dendrimers:: Tunable membrane-impermeable fluorescent pH nanosensors [J].

Finikova, O ;

Galkin, A ;

Rozhkov, V ;

Cordero, M ;

Hägerhäll, C ;

Vinogradov, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (16) :4882-4893

[6]

Fluorescence probe with a pH-sensitive trigger [J].

Galande, AK ;

Weissleder, R ;

Tung, CH .

BIOCONJUGATE CHEMISTRY, 2006, 17 (02) :255-257

[7]

Biological evaluation of polyester dendrimer:: Poly(ethylene oxide) "Bow-Tie" hybrids with tunable molecular weight and architecture [J].

Gillies, Elizabeth R. ;

Dy, Edward ;

Frechet, Jean M. J. ;

Szoka, Francis C. .

MOLECULAR PHARMACEUTICS, 2005, 2 (02) :129-138

[8]

Dendrimers and dendritic polymers in drug delivery [J].

Gillies, ER ;

Fréchet, JMJ .

DRUG DISCOVERY TODAY, 2005, 10 (01) :35-43

[9]

Designing macromolecules for therapeutic applications:: Polyester dendrimer-poly(ethylene oxide) "bow-tie" hybrids with tunable molecular weight and architecture [J].

Gillies, ER ;

Fréchet, JMJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (47) :14137-14146

[10]

PH imaging [J].

Gillies, RJ ;

Raghunand, N ;

Garcia-Martin, ML ;

Gatenby, RA .

IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, 2004, 23 (05) :57-64

← 1 2 3 →