Pathogenesis of Kaposi's sarcoma

被引：35

作者：

Bubman, D

Cesarman, E ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA

[2] Cornell Univ, Weill Grad Sch Med Sci, Pharmacol Programme, New York, NY 10021 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2003年 / 17卷 / 03期

关键词：

D O I：

10.1016/S0889-8588(03)00044-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Kaposi's sarcoma (KS) is a disease characterized by proliferative vascular lesions, which almost invariably contain the KS-associated herpesvirus (KSHV), also called human herpesvirus 8. KSHV is a lymphotrophic and angiotropic herpesvirus, whose genome encodes several proteins involved in proliferation, antiapoptotic functions, and inflammation. Most KS spindle cells express latent KSHV genes, but a few express lytic genes, which might be involved in angiogenic and paracrine mechanisms that contribute to KS pathogenesis. A number of tissue culture and mouse models have been established, but a comprehensive system that accurately portrays KS pathogenesis still does not exist.

引用

页码：717 / +

页数：30

共 231 条

[1]

Aboulafia DM, 1998, MAYO CLIN PROC, V73, P439

[2]

Integrin α3β1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells [J].