Mobile elements and disease

被引：153

作者：

Kazazian, HH ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-437X(98)80092-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A substantial fraction of mammalian genomes is composed of mobile elements and their remnants. Recent insertions of LTR-retrotransposons, non-LTR retrotransposons, and non-autonomous retrotransposons have caused disease frequently in mice, but infrequently in humans. Although many of these elements are defective, a number of mammalian non-LTR retrotransposons of the L1 type are capable of autonomous retrotransposition. The mechanism by which they retrotranspose and in turn aide the retrotransposition of non-autonomous elements is being elucidated.

引用

页码：343 / 350

页数：8

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