Malignant astrocytic glioma: genetics, biology, and paths to treatment

被引：1873

作者：

Furnari, Frank B.

Fenton, Tim

Bachoo, Robert M.

Mukasa, Akitake

Stommel, Jayne M.

Stegh, Alexander

Hahn, William C.

Ligon, Keith L.

Louis, David N.

Brennan, Cameron

Chin, Lynda

DePinho, Ronald A.

Cavenee, Webster K.

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Ctr Appl Canc Sci,Belfer Inst Innovat Canc Sci, Boston, MA 02115 USA

[2] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Ctr Canc, La Jolla, CA 92093 USA

[5] Univ Texas, SW Med Sch, Dept Neurol, Dallas, TX 75390 USA

[6] Univ Texas, SW Med Sch, Dept Med, Dallas, TX 75390 USA

[7] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[9] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med, Boston, MA 02115 USA

[10] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Genet, Boston, MA 02115 USA

[11] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[12] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA

[13] Mem Sloan Kettering Canc Ctr, Dept Neurosurg, New York, NY 10065 USA

[14] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Dermatol, Boston, MA 02115 USA

[15] Univ Calif San Diego, Ctr Mol Genet, La Jolla, CA 92093 USA

来源：

GENES & DEVELOPMENT | 2007年 / 21卷 / 21期

关键词：

D O I：

10.1101/gad.1596707

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal intracranial tumors. These cancers exhibit a relentless malignant progression characterized by widespread invasion throughout the brain, resistance to traditional and newer targeted therapeutic approaches, destruction of normal brain tissue, and certain death. The recent confluence of advances in stem cell biology, cell signaling, genome and computational science and genetic model systems have revolutionized our understanding of the mechanisms underlying the genetics, biology and clinical behavior of glioblastoma. This progress is fueling new opportunities for understanding the fundamental basis for development of this devastating disease and also novel therapies that, for the first time, portend meaningful clinical responses.

引用

页码：2683 / 2710

页数：28

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