HTRA proteases: regulated proteolysis in protein quality control

被引：379

作者：

Clausen, Tim ^{[1
]}

Kaiser, Markus ^{[2
]}

Huber, Robert ^{[2
,3
,4
]}

Ehrmann, Michael ^{[2
,4
]}

机构：

[1] Res Inst Mol Pathol IMP, A-1030 Vienna, Austria

[2] Univ Duisburg Essen, Ctr Med Biotechnol, Fac Biol, D-45117 Essen, Germany

[3] Max Planck Inst Biochem, D-82152 Martinsried, Germany

[4] Cardiff Univ, Sch Biosci, Cardiff CF10 3US, S Glam, Wales

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 03期

关键词：

HIGH-TEMPERATURE REQUIREMENT; AMYLOID PRECURSOR PROTEIN; IGF-BINDING PROTEINS; ENVELOPE-STRESS-RESPONSE; GROWTH-FACTOR IGF; SERINE-PROTEASE; ESCHERICHIA-COLI; PHOTOSYSTEM-II; PDZ DOMAIN; CRYSTAL-STRUCTURE;

D O I：

10.1038/nrm3065

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Controlled proteolysis underlies a vast diversity of protective and regulatory processes that are of key importance to cell fate. The unique molecular architecture of the widely conserved high temperature requirement A (HTRA) proteases has evolved to mediate critical aspects of ATP-independent protein quality control. The simple combination of a classic Ser protease domain and a carboxy-terminal peptide-binding domain produces cellular factors of remarkable structural and functional plasticity that allow cells to rapidly respond to the presence of misfolded or mislocalized polypeptides.

引用

收藏

页码：152 / 162

页数：11

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[1] Identification of Novel Substrates for the Serine Protease HTRA1 in the Human RPE Secretome [J].

An, Eunkyung ;

Sen, Supti ;

Park, Sung Kyu ;

Gordish-Dressman, Heather ;

Hathout, Yetrib .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (07) :3379-3386

[2] New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays [J].

Baell, Jonathan B. ;

Holloway, Georgina A. .

JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (07) :2719-2740

[3] The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells [J].

Baldi, A ;

De Luca, A ;

Morini, M ;

Battista, T ;

Felsani, A ;

Baldi, F ;

Catricalà, C ;

Amantea, A ;

Noonan, DM ;

Albini, A ;

Natali, PG ;

Lombardi, D ;

Paggi, MG .

ONCOGENE, 2002, 21 (43) :6684-6688

[4] Role of DegP for two-partner secretion in Bordetella [J].

Baud, C. ;

Hodak, H. ;

Willery, E. ;

Drobecq, H. ;

Locht, C. ;

Jamin, M. ;

Jacob-Dubuisson, F. .

MOLECULAR MICROBIOLOGY, 2009, 74 (02) :315-329

[5] Methylation Induced Gene Silencing of HtrA3 in Smoking-Related Lung Cancer [J].

Beleford, Daniah ;

Liu, Zhixue ;

Rattan, Ramandeep ;

Quagliuolo, Lucio ;

Boccellino, Mariarosaria ;

Baldi, Alfonso ;

Maguire, Jacie ;

Staub, Julie ;

Molina, Julian ;

Shridhar, Viji .

CLINICAL CANCER RESEARCH, 2010, 16 (02) :398-409

[6] High Temperature Requirement A3 (HtrA3) Promotes Etoposide- and Cisplatin-induced Cytotoxicity in Lung Cancer Cell Lines [J].

Beleford, Daniah ;

Rattan, Ramandeep ;

Chien, Jeremy ;

Shridhar, Viji .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (16) :12011-12027

[7] Role of HtrA in surface protein expression and biofilm formation by Streptococcus mutans [J].

Biswas, S ;

Biswas, I .

INFECTION AND IMMUNITY, 2005, 73 (10) :6923-6934

[8] INDUCTION OF BOVINE TRYPSINOGEN-TRYPSIN TRANSITION BY PEPTIDES SEQUENTIALLY SIMILAR TO N-TERMINUS OF TRYPSIN [J].

BODE, W ;

HUBER, R .

FEBS LETTERS, 1976, 68 (02) :231-236

[9] THE REFINED 1.9 A CRYSTAL-STRUCTURE OF HUMAN ALPHA-THROMBIN - INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT [J].

BODE, W ;

MAYR, I ;

BAUMANN, U ;

HUBER, R ;

STONE, SR ;

HOFSTEENGE, J .

EMBO JOURNAL, 1989, 8 (11) :3467-3475

[10] TRANSITION OF BOVINE TRYPSINOGEN TO A TRYPSIN-LIKE STATE UPON STRONG LIGAND-BINDING - REFINED CRYSTAL-STRUCTURES OF BOVINE TRYPSINOGEN-PANCREATIC TRYPSIN-INHIBITOR COMPLEX AND OF ITS TERNARY COMPLEX WITH ILE-VAL AT 1.9 A RESOLUTION [J].

BODE, W ;

SCHWAGER, P ;

HUBER, R .

JOURNAL OF MOLECULAR BIOLOGY, 1978, 118 (01) :99-112

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