Mouse models of osteoarthritis provide new research tools

被引：24

作者：

Young, MF ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Mol Biol Bones & Teeth Unit, Craniofacial & Skeletal Dis Branch, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 07期

关键词：

D O I：

10.1016/j.tips.2005.05.001

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The options for pharmaceutical intervention of osteoarthritis are limited. There is therefore a crucial need for animal models of osteoarthritis that can be used as research tools for improving our understanding of the disease and for discovering and testing new treatments. Recently, a new mouse model of osteoarthritis was described in which the mice are unable to produce a bone morphogenetic protein (BMP) receptor specifically in joints. A comparison of this model to other models with different etiologies is presented. The findings suggest that all of the models could be linked molecularly.

引用

页码：333 / 335

页数：3

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