Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees

被引：20

作者：

Bagarazzi, ML

Boyer, JD

Ugen, KE

Javadian, MA

Chattergoon, M

Shah, A

Bennett, M

Ciccarelli, R

Carrano, R

Coney, L

Weiner, DB

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] Allegheny Univ Hlth Sci, St Christophers Hosp Children, Dept Pediat, Philadelphia, PA 19134 USA

[3] Univ S Florida, Tampa, FL 33612 USA

[4] Coulston Fdn, Alamogordo, NM 88310 USA

[5] Apollon Inc, Malvern, PA 19355 USA

来源：

VACCINE | 1998年 / 16卷 / 19期

关键词：

antibody; CTL; lymphocyte proliferation; flow cytometry; mucosal; primate; immunization; gene; plasmid;

D O I：

10.1016/S0264-410X(98)00178-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with out plasmid vaccines. We have found these vaccines to be safe and well tolerated in all of these groups. The same vaccines have induced both humoral and cellular immunity in each instance. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：1836 / 1841

页数：6

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