[1] Univ Paris 06, Ctr Rech Cordeliers, UMRS 872, F-75006 Paris, France
[2] Univ Paris 05, UMRS 872, F-75006 Paris, France
[3] INSERM, U872, F-75006 Paris, France
[4] Univ Oxford, Jenner Inst, Compton RG20 7NN, Berks, England
[5] GlaxoSmithKline Inc, Target Discovery, RI CEDD, Stevenage SG1 2NY, Herts, England